Triprolidine (Actidil) is an anhistamine molecule having chemical name: Trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene. It is used in making a popular Actifed drug.

VMSRF has now developed a patent non-infringing process which is very cost effective and ready for commercialization. The best advantage of our process is elimination of the usage of hazardous butyl lithium which is hitherto used to make this drug.

Triprolidine (Actidil)
  1. It is an antihistamine originally invented and patented by BurroughsWellcome Foundation in 1955
  2. Its chemical name is Trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene.
  3. VMSRF has now developed a patent noninfringing process
The advantages of our process are
  • a)The usage of hazardous butyl lithium which is being used to make it is completely eliminated in our process
  • b)Cost effective
  • c)Can be easily scaled up and ready for commercialization.
Patent filed by VMSRF
  • Indian patent application 992/CHE/2006 filed on 14th July 2006
PCT filed by VMSRF
  • PCT /IN07/000102 filed on 12th March 2007